Automated purification and formulation device for radiopharmaceutical compounds

US10589250B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• SOFIE BIOSCIENCES, INC. · US

Inventors

• Eric Schopf · Solana Beach, US
• Melissa Moore · Chicago, US
• R. Michael Van Dam · Los Angeles, US
• Brandon Maraglia · Culver City, US
• Alexander Hsiao · Los Angeles, US

Key dates

• Filing date: Sep 7, 2017
• Grant date: Mar 17, 2020
• Expiry date: Mar 25, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G21G4/08
• WIPO field: Engines, pumps, turbines
• WIPO sector: Mechanical engineering

Abstract

A device for purifying and formulating a radiopharmaceutical compound includes an automated purification subsystem that automates the loading of a sample into a sample loop for downstream purification via HPLC. A column selector valve is provided to select from one of a plurality of columns. Fractions can be collected as well as the desired product. The device includes an automated formulation subsystem that first sends the product to a dilution reservoir prior to being pneumatically pushed onto a solid phase extraction (SPE) cartridge. Automated rinse, elution, and reconstitution are also performed with the automated formulation subsystem. The device may be directly coupled to the output of an automated radiosynthesizer.