Mitochondria-targeting fluorescent potassium+ sensor and method of making the same
US10590155B2 · kind B2 · utility
3Cited by
8References
9Claims
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Key dates
| Filing date | Jul 14, 2017 |
| Grant date | Mar 17, 2020 |
| Priority date | — |
| Expiry date | Jul 14, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/6872
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Mitochondria-targeting potassium sensors and method(s) for making such sensors. The sensor shows a response to potassium and displays a 130-fold dynamic range of fluorescence intensity and high brightness. The sensors response to potassium concentrations was demonstrated to be unaffected by cellular pH value and/or concentrations of other ions. The sensors can be used for monitoring the mitochondrial potassium efflux/influx.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.