Patent · US Active

System for conditioning of engineered microtissues

US10590376B2 · kind B2 · utility

0Cited by

5References

17Claims

0Family size

Assignee

THE JOHNS HOPKINS UNIVERSITY · US

Inventors

Daniel H. Reich · Baltimore, US
Fan Xu · Novi, US
Ruogang Zhao · Baltimore, US
Alan S. Liu · Palo Alto, US
Tristin Metz · Baltimore, US
Yu Shi · Beijing, CN

Key dates

Filing date	Nov 20, 2015
Grant date	Mar 17, 2020
Priority date	—
Expiry date	Jul 8, 2036

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01L3/508
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A system and method for conditioning a tissue are provided. The system includes a substrate, a plurality of microwells formed in the substrate, and a microsphere associated with each of the plurality of microwells. The system also includes a pair of flexible pillars within each of the plurality of microwells. Each flexible pillar includes a first end bonded to a respective microwell and at least one flexible pillar has a second end bonded to the microsphere. The flexible pillars are configured to deflect when exposed to a magnetic field to controllably stretch microtissue spanning the flexible pillars.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.