Methods for differentiating pluripotent cells
US10590383B2 · kind B2 · utility
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Key dates
| Filing date | Aug 16, 2017 |
| Grant date | Mar 17, 2020 |
| Priority date | — |
| Expiry date | Sep 10, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/5073
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are provided, in some aspects, for differentiating pluripotent cells into midbrain dopaminergic (DA) neurons using a mono-SMAD inhibition or inhibition of SMAD signaling with only one SMAD inhibitor. In some embodiments, mono-SMAD inhibition utilizes a single inhibitor of bone morphogenic protein (BMP) for differentiating pluripotent cells into midbrain DA neurons.
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