Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof

US10590566B2 · kind B2 · utility

Assignee

• Tepha, Inc. · US

Inventors

• Amit Ganatra · Attleboro, US
• Fabio Felix · Foxborough, US
• Bhavin Shah · Lowell, US
• Matthew Bernasconi · Norwood, US
• Said Rizk · Windham, US
• David P. Martin · Arlington, US
• Simon F. Williams · Sherborn, US

Key dates

• Filing date: Mar 19, 2018
• Grant date: Mar 17, 2020
• Expiry date: Mar 19, 2038

Classification

• Technology area (CPC D): Textiles; Paper
• CPC primary: D10B2509/08
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.