Automatic structure determination

US10591501B2 · kind B2 · utility

Inventors

• Torsten Matthias · Flonheim, DE
• Hans-Peter Schimon · Bad Boll, DE
• Jens Blecken · Dettelbach, DE
• Markus Wulf · Wixom, US
• Matthias Wende · Mommenheim, DE

Key dates

• Filing date: Oct 29, 2012
• Grant date: Mar 17, 2020
• Expiry date: Jun 3, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2035/0441
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to an automated method for the optical analysis of structures, in particular for the analysis and determination of biological cellular structures, and to an apparatus for this purpose, wherein an electro-optical unit generates an electronic image of two- and three-dimensional structures present in the sample, a storage medium stores the image, a computer-controlled displacement device establishes an optimized image sharpness of the image by changing the distance between sample and the optical unit, wherein the displacement device is controlled by contrast analysis and color value detection, and a computer unit compares the images generated by the electro-optical unit of two- and/or three-dimensional structures with the known structures stored in a database, and the structures registered by the optical unit are assigned by means of an algorithm to characteristic grids, structures or patterns.