Residence structures and related methods

US10596110B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Andrew Bellinger · Wellesley, US
• Shiyi Zhang · Shanghai, CN
• Carlo Giovanni Traverso · Newton, US
• Robert S. Langer · Newton, US
• Stacy Mo · Darien, US
• Tyler Grant · Arlington, US
• Mousa Jafari · Waltham, US
• Dean Liang Glettig · Cambridge, US
• Angela DiCiccio · San Francisco, US
• Omar Abouzid · Cambridge, US
• Ameya R. Kirtane · Minneapolis, US

Key dates

• Filing date: Jun 21, 2018
• Grant date: Mar 24, 2020
• Expiry date: Aug 17, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controll…