Antagonists of the thyroid-stimulating hormone receptor (TSHR)

US10596168B2 · kind B2 · utility

Assignee

• Forschungsverbund Berlin e.V. · DE

Inventors

• Gerd Krause · Berlin, DE
• Inna Hoyer · Panketal, DE
• Edgar Specker · Berlin, DE
• Jens Furkert · Glienicke, DE
• Patrick Marcinkowski · Berlin, DE
• Jens-Peter Von Kries · Panketal, DE
• Martin NEUENSCHWANDER · Berlin, DE
• Marc Nazare · Idstein, DE

Key dates

• Filing date: Apr 26, 2017
• Grant date: Mar 24, 2020
• Expiry date: Apr 26, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Chemical compounds are useful in the treatment of a subject afflicted by a thyroid disease. The compounds exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and can be used in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.