Polypeptide targeting to mitochondria
US10596227B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Sep 21, 2015 |
| Grant date | Mar 24, 2020 |
| Priority date | — |
| Expiry date | Oct 12, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y306/03014
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.