Process and intermediates for the preparation of benzo[b]thiophene compounds

US10597386B2 · kind B2 · utility

Assignee

• CRYSTAL PHARMA, S.A.U. · ES

Inventors

• Alfonso Pérez Encabo · Valladolid, ES
• José Ángel TURIEL HERNANDEZ · Valladolid, ES
• Yolanda Fernández Sainz · Valladolid, ES
• Antonio Lorente Bonde-Larsen · Laguna de Duero, ES

Key dates

• Filing date: Sep 30, 2016
• Grant date: Mar 24, 2020
• Expiry date: Sep 30, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.