Patent · US Active

Bis-alkoxyl amide alkyl cationic peptide lipids, synthesis method thereof, and application thereof

US10597678B2 · kind B2 · utility

0Cited by

0References

7Claims

0Family size

Assignee

DALIAN NATIONALITIES UNIVERSITY · CN

Inventors

Shubiao Zhang · 东风镇, CN
Yinan Zhao · Shanghai, CN
Shaohui Cui · 东风镇, CN
Huiying Chen · 东风镇, CN
Quan Zhou · Beijing, CN

Key dates

Filing date	Jun 25, 2015
Grant date	Mar 24, 2020
Priority date	—
Expiry date	Jun 25, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K5/1019
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A bis-alkoxyl amide alkyl cationic peptide lipid has a chemical structure as below: wherein the bis-alkoxyl amide alkyl cationic peptide lipid is dispersed in water to obtain the cationic peptide liposome which are high in stability and uniform in dispersion and have about 120 nm of average grain diameter and Zeta electric potential between 30 and 50 mV. The liposome can effectively compress the plasmids DNA and siRNA, can efficient transfection both in-vitro and in-vivo, and almost does not have toxicity to cells and mice, so that the liposome can be widely applied in gene delivery as a gene vector.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.