Patent · US Active

Method of calibrating a mass spectrometer

US10600625B2 · kind B2 · utility

0Cited by

9References

51Claims

0Family size

Assignee

THERMO FISHER SCIENTIFIC (BREMEN) GMBH · DE

Inventors

Norbert Quaas · Bremen, DE
Hans-Juergen Schlueter · Bremen, DE
Gerhard Jung · Delmenhorst, DE

Key dates

Filing date	Aug 11, 2017
Grant date	Mar 24, 2020
Priority date	—
Expiry date	Aug 11, 2037

Classification

Technology area (CPC H)Electricity
CPC primaryH01J49/4225
WIPO fieldElectrical machinery, apparatus, energy
WIPO sectorElectrical engineering

Abstract

A method of calibrating a mass spectrometer is disclosed. The mass spectrometer includes a first quadrupole, a second mass analyzer and a detection means. The method includes calibrating the second mass analyzer at a first time, calibrating the first quadrupole at a second time later than the first including a) determining for each of several selected masses a corresponding value of the amplitude of the RF voltage and DC voltage applied to the electrodes of the first quadrupole, b) fitting a function of the selected mass to the values of the amplitude of the RF voltage and DC voltage corresponding to the several selected masses, c) detecting the selected mass in a filter window width over a mass range, d) evaluating a shift of the peak position and/or a deviation of the filter window width, and e) repeating the calibration steps under certain conditions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.