Prediction of preictal state and seizure onset zones based on high frequency oscillations
US10602941B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 30, 2017 |
| Grant date | Mar 31, 2020 |
| Priority date | — |
| Expiry date | Aug 5, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/0529
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A seizure preemption system including electrodes for recording simultaneous electroencephalographic (EEG) signals from a subject, a controller electrically coupled to the electrodes, and a neuromodulator electrically coupled to the controller. The controller is configured to sample the simultaneous EEG signals, identify high frequency oscillation (HFO) events in each EEG signal, and extract one or more features from each EEG signal to yield HFO profiles for the HFOs recorded from each EEG signal. Based on the HFO profiles for the EEG signal, the controller is configured to identify each EEG signal as associated with a preictal state or an interictal state of the subject. The neuromodulator is configured to deliver electrical stimulations to one or more seizure foci of the subject's brain via one or more of the electrodes in response to identification of at least one EEG signal as associated with a preictal state of the subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.