Energy modulated luminescence tomography

US10603001B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Robert John Filkins · Niskayuna, US
• Ahmad Nadeem Ishaque · Clifton Park, US
• Alok Mani Srivastava · San Francisco, US
• Peter William Lorraine · Niskayuna, US
• Holly Ann Comanzo · Niskayuna, US
• Xiaolei Shi · Nanhu, CN
• Vasile Bogdan Neculaes · Niskayuna, US
• Sam Joseph Camardello · Saratoga Springs, US
• Gregory Boverman · Niskayuna, US
• Ge Wang · Beijing, CN
• Wenxiang Cong · Albany, US

Key dates

• Filing date: Jul 1, 2015
• Grant date: Mar 31, 2020
• Expiry date: Nov 29, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0065
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present approach generally relates to systems and methods for implementing energy modulated tomographic imaging of nanoparticles. In certain embodiments, a first energy is used to activate probe particles labeling an anatomy or tissue of interest. The probe particles, once activated, emit photons at a different rate and/or spectrum in response to an underlying physiological event, such as action potentials propagating in the labeled anatomy or tissue. The emitted photons may then be detected and used to map or image the occurrence of the physiological event.