Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity

US10603334B2 · kind B2 · utility

Assignee

• NewSouth Innovations Pty Limited · AU

Inventors

• Lindsay Edward Wu · Sydney, AU
• David A. Sinclair · Feldkirchen-Westerham, DE

Key dates

• Filing date: Apr 28, 2016
• Grant date: Mar 31, 2020
• Expiry date: Apr 28, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y207/07001
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.