Monoclonal antibodies to growth and differentiation factor 15 (GDF-15), and uses thereof for treating cancer cachexia and cancer

US10604565B2 · kind B2 · utility

Assignee

• Julius-Maximilians-Universitat Wurzburg · DE

Inventors

• Jörg WISCHHUSEN · Würzburg, DE
• Markus Junker · Würzburg, DE
• Tina SCHÄFER · Würzburg, DE
• Dirk PÜHRINGER · Rimpar, DE

Key dates

• Filing date: Mar 5, 2018
• Grant date: Mar 31, 2020
• Expiry date: May 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/63
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric antibodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine antibodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.