Diagnosis and therapy of cancer involving cancer stem cells

US10604568B2 · kind B2 · utility

Assignees

• BioNTech AG · DE
• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE
• ASTELLAS PHARMA INC. · JP

Inventors

• Ugur Sahin · Mainz, DE
• Ozlem Tureci · Homburg, DE
• Korden Walter · Mainz, DE
• Meike Wagner · Mainz, DE
• Maria Kreuzberg · Mainz, DE
• Sabine Hacker · Mainz, DE
• Stefan Jacobs · Mainz, DE

Key dates

• Filing date: Jul 30, 2014
• Grant date: Mar 31, 2020
• Expiry date: Jul 30, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.