Patent · US Active

Transcription factor mediated programming towards megakaryocytes

US10604738B2 · kind B2 · utility

2Cited by

14References

15Claims

0Family size

Assignee

Cambridge Enterprise Limited · GB

Inventors

Roger Pedersen · Cambridge, GB
Willem Ouwehand · London, GB
Thomas Moreau · Mougins, FR
Cedric Ghevaert · Cambridge, GB
Matthew William Burnell Trotter · Sevilla, ES

Key dates

Filing date	Jun 19, 2013
Grant date	Mar 31, 2020
Priority date	—
Expiry date	Jul 17, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/003
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

This invention relates to the forward programming of pluripotent stem cells (PSCs) into megakaryocyte (MK) progenitor cells using the transcription factors GATA1, FLI1 and TAL1. Methods of producing megakaryocyte (MK) progenitor cells and subsequently differentiating them into mature megakaryocytes are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.