Nucleic acids encoding chimeric antigen receptor proteins which bind epidermal growth factor receptor and T lymphocyte expressing the protein
US10604740B2 · kind B2 · utility
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Key dates
| Filing date | May 14, 2014 |
| Grant date | Mar 31, 2020 |
| Priority date | — |
| Expiry date | May 14, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/15043
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A nucleic acid for coding a chimeric antigen receptor protein expressed on the surface of a human T lymphocyte. The chimeric antigen receptor protein comprises an extracellular binding domain, a transmembrane domain and an intracellular signal domain that are orderly connected. The extracellular binding domain comprises a single-chain antibody scFv (EGFR) for specific recognition of 287th to 302nd amino acid epitopes of a human epidermal growth factor receptor (EGFR).
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