Methods and compositions for enhancing the efficacy and specificity of RNA silencing
US10604754B2 · kind B2 · utility
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10References
25Claims
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Key dates
| Filing date | Jun 3, 2014 |
| Grant date | Mar 31, 2020 |
| Priority date | — |
| Expiry date | Sep 21, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are also featured.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.