Residence structures and related methods

US10610482B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US
• TOKITAE LLC · US

Inventors

• Andrew Bellinger · Wellesley, US
• Shiyi Zhang · Shanghai, CN
• Carlo Giovanni Traverso · Newton, US
• Robert S. Langer · Newton, US
• Stacy Mo · Darien, US
• Tyler Grant · Arlington, US
• Mousa Jafari · Waltham, US
• Dean Liang Glettig · Cambridge, US
• Angela DiCiccio · San Francisco, US
• Lowell L. Wood, Jr. · Bellevue, US
• Philip A. Eckhoff · Bellevue, US

Key dates

• Filing date: Nov 1, 2018
• Grant date: Apr 7, 2020
• Expiry date: Nov 1, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain embodiments comprise administering a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance, and, optionally, a linker. In some such embodiments, the linker may be configured to degrade.