Patent · US Active

Composition comprising an organic liquid diluent and a specific hydroxyalkyl methylcellulose

US10610491B2 · kind B2 · utility

0Cited by

5References

20Claims

0Family size

Assignee

DOW GLOBAL TECHNOLOGIES LLC · US

Inventors

Meinolf Brackhagen · Walsrode, DE
Matthias Knarr · Nienburg/Weser, DE
Roland Adden · Bad Fallingbostel, DE

Key dates

Filing date	Sep 15, 2014
Grant date	Apr 7, 2020
Priority date	—
Expiry date	Sep 15, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08L1/284
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A liquid composition which comprises an organic liquid diluent and a hydroxyalkyl methylcellulose which has a certain distribution of substituted hydroxyalkoxyl groups and unsubstituted hydroxyalkoxyl groups is stable over an extended time period. In the hydroxyalkyl methylcellulose hydroxyalkoxyl groups are classified into a fraction (A) and a fraction (B), wherein fraction (A) represents the sum of all molar fractions of substituted hydroxyalkoxyl groups having hydroxyl groups substituted further with methoxyl groups and fraction (B) represents the sum of all molar fractions of unsubstituted hydroxyalkoxyl groups having hydroxyl groups not substituted further with methoxyl groups and wherein the ratio fraction (A)/fraction (B) is at least 0.30. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.