Alpha-cell re-generation combined with conversion to beta cells
US10610504B2 · kind B2 · utility
1Cited by
2References
11Claims
0Family size
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Key dates
| Filing date | Dec 23, 2015 |
| Grant date | Apr 7, 2020 |
| Priority date | — |
| Expiry date | Mar 20, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of generating a population of beta cells from a population of alpha cells, by contacting said population of alpha cells with GABA or a GABA receptor agonist, in combination with a monoclonal glucagon neutralizing antibody or other alpha cell mass regulating compounds, for an improved diabetes therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.