P2X3 and/or P2X2/3 compounds and methods

US10611768B2 · kind B2 · utility

Assignee

• Asana BioSciences, LLC · US

Inventors

• Scott K. Thompson · Phoenixville, US
• Tony Priestley · West Chester, US
• Mrinalkanti Kundu · Jharia, IN
• Ashis Saha · Stow, US
• Suvadeep Nath · Sherghati, IN

Key dates

• Filing date: Nov 30, 2018
• Grant date: Apr 7, 2020
• Expiry date: Nov 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.