Nucleic acids encoding hemojuvelin fusion proteins and uses thereof

US10611820B2 · kind B2 · utility

Assignee

• The General Hospital Corporation · US

Inventors

• Herbert Y. Lin · Watertown, US
• Jodie Babitt · Newton, US
• Clifford J. Woolf · Newton, US
• Tarek A. Samad · Boston, US

Key dates

• Filing date: Aug 21, 2017
• Grant date: Apr 7, 2020
• Expiry date: Aug 21, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof.