Non-human primate-derived pan-ebola and pan-filovirus monoclonal antibodies directed against envelope glycoproteins

US10611827B2 · kind B2 · utility

Assignees

• INTEGRATED BIOTHERAPEUTICS, INC. · US
• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Mohammad Javad Aman · Rockville, US
• Frederick Wayne Holtsberg · Rockville, US
• Sven G. Enterlein · Berlin, DE
• Katie A. Howell · North Bethesda, US
• Zhen-Yong Keck · Redwood City, US
• Steven Foung · Stanford, US

Key dates

• Filing date: Oct 27, 2015
• Grant date: Apr 7, 2020
• Expiry date: Oct 27, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides non-human primate-derived binding molecules, e.g., antibodies or antigen-binding fragments thereof, that can bind to orthologous epitopes found on two or more filovirus species or strains.