Methods of expanding and assessing B cells and using expanded B cells to treat disease
US10611999B2 · kind B2 · utility
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Key dates
| Filing date | Jun 5, 2018 |
| Grant date | Apr 7, 2020 |
| Priority date | — |
| Expiry date | Jun 5, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/599
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21. Compositions comprising the ex vivo expanded B cells and methods of using the expanded B cell-containing compositions to treat diseases or conditions are also provided. Methods of assessing B10 cell function in a subject are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.