Genetic markers for engraftment of human cardiac ventricular progenitor cells
US10612094B2 · kind B2 · utility
4Cited by
7References
38Claims
0Family size
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Key dates
| Filing date | Feb 15, 2017 |
| Grant date | Apr 7, 2020 |
| Priority date | — |
| Expiry date | Aug 19, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides genetic markers for identifying engraftable human cardiac ventricular progenitor cells. The engraftment markers of the invention include angiogenic markers and extracellular matrix markers. Human ventricular progenitor cells expressing these markers are capable of forming ventricular tissue in vivo that is vascularized and supported by an extracellular matrix. Methods of engrafting human cardiac ventricular progenitor cells by transplanting into a subject progenitor cells that express the engraftment markers are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.