Methods and systems of assessing tissue vascular permeability using non-labeled dextran
US10613180B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 6, 2015 |
| Grant date | Apr 7, 2020 |
| Priority date | — |
| Expiry date | Jun 14, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/56366
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of assessing tissue vascular permeability for nanotherapeutics using non-labeled dextran can include: receiving a non-labeled, physiologically-tolerable dextran solution by a subject; acquiring a plurality of magnetic resonance images of a distribution of the dextran solution within at least one region of interest of the subject for a corresponding plurality of times; and assessing a tissue vascular permeability of the at least one region of interest to dextran particles in the dextran solution based on differences between the plurality of magnetic resonance images, wherein the dextran solution is a substantially mono-disperse solution of dextran particles of one size.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.