Methods for treating and preventing neutrophil-derived net toxicity and thrombosis
US10617742B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Mar 30, 2017 |
| Grant date | Apr 14, 2020 |
| Priority date | — |
| Expiry date | Mar 30, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/21001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries e.g., preventing transfusion-related acute lung injury (TRALI), by treating blood transfusion products with an anti-Neutrophil Extracellular Trap (NET) compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.