Hydroxyl purine compounds and use thereof

US10618898B2 · kind B2 · utility

Assignee

• GUANGDONG RAYNOVENT BIOTECH CO., LTD. · CN

Inventors

• Linyun Wu · Zhuqiao, CN
• Xiaoxin Chen · Cupertino, US
• Peng Zhang · Nanhu, CN
• Xing Liu · Hefei, CN
• Li Zhang · New Milford, US
• Zhuowei Liu · 流花街道, CN
• Shuhui CHEN · Shanghai, CN
• Chaofeng Long · Tangxia, CN

Key dates

• Filing date: May 5, 2016
• Grant date: Apr 14, 2020
• Expiry date: May 5, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are a series of hydroxyl purine compounds and the use thereof as PDE2 or TNFα inhibitors, in particular, the compounds as shown in formula (I), or tautomers or pharmaceutically acceptable salts thereof.