Antibody-drug conjugate (ADC) and method for forming the same
US10618935B2 · kind B2 · utility
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Key dates
| Filing date | Nov 2, 2016 |
| Grant date | Apr 14, 2020 |
| Priority date | — |
| Expiry date | Nov 25, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0207
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided. A-(L-D)p (I)
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