Aptamers and diagnostic methods for detecting the EGF receptor
US10620210B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 5, 2017 |
| Grant date | Apr 14, 2020 |
| Priority date | — |
| Expiry date | May 5, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3′ cap. In some embodiments, the 3′ cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5′-end of the aptamer and the moiety is attached the 5′ end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.