Real-time imaging sensor for measuring cellular thiol level
US10620215B2 · kind B2 · utility
1Cited by
1References
12Claims
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Key dates
| Filing date | Jan 2, 2019 |
| Grant date | Apr 14, 2020 |
| Priority date | — |
| Expiry date | Jan 2, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7042
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a fluorescence sensor capable of real-time imaging for measuring a cellular thiol level. The present invention reveals that the fluorescence intensity of the fluorescent real-time SH group-tracer (FreSH-Tracer) of the present invention increases or decreases continuously, ratiometrically or reversibly depending on the thiol level in living cells, and thus can be usefully used as a biosensor which is remarkably susceptible to quantitative or qualitative real-time detection of the cellular thiol level in living cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.