Patent · US Active

Method and device for correcting level of expression of small RNA

US10622093B2 · kind B2 · utility

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11Claims
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Key dates

Filing dateNov 25, 2015
Grant dateApr 14, 2020
Priority date
Expiry dateNov 25, 2035

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q2600/178
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

A method of correcting an expression level(s) of a target small RNA(s) for comparative analysis of the expression level(s) in a plurality of samples includes adding at least one kind of standard substance to each of the plurality of samples, extracting nucleic acids from each sample to obtain a nucleic acid sample; measuring the amounts of the target small RNA(s) and the standard substance(s) present in each extracted nucleic acid sample; obtaining a representative value from the measured value(s) of the amount(s) of the standard substance(s) extracted; obtaining the difference or the ratio between a reference value arbitrarily set in connection with the amount(s) of the standard substance(s) extracted and the representative value of the standard substance(s) obtained for each sample; and correcting the expression level(s) of the target small RNA(s).

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