Patent · US Active

Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol

US10626123B2 · kind B2 · utility

1Cited by

2References

8Claims

0Family size

Assignee

H. LUNDBECK A/S · DK

Inventors

Carla De Faveri · Isola di Terranegra, IT
Florian Huber · Grassau, DE

Key dates

Filing date	Mar 22, 2016
Grant date	Apr 21, 2020
Priority date	—
Expiry date	Mar 22, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D491/113
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-5 dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.