Culture scaffold for enhancing differentiation of osteoblast using pattern
US10626373B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 7, 2017 |
| Grant date | Apr 21, 2020 |
| Priority date | — |
| Expiry date | Sep 4, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2535/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure relates to a culture scaffold for promoting differentiation from stem cells or precursor cells into osteoblasts, in which the culture scaffold includes a structure composed of a ridge and a groove, a kit using the culture scaffold, and a method for differentiating stem cells or precursor cells into osteoblasts. The culture scaffold of the present disclosure has an optimal pattern depending on the type of stem cells or precursor cells, thereby improving the osteoblast differentiation potency. In particular, it has a feature of showing excellent osteoblast differentiation potency even if only a small amount of supplementary factors inducing osteoblast differentiation is added. Furthermore, since the osteoblast differentiation potency is not greatly influenced by the change in cell density, it is possible to induce differentiation into osteoblasts without being influenced by the inflammatory environment formed by the inflammatory factors that increase upon cell differentiation. Thus, there is an advantage in that the differentiation efficiency into osteoblasts is high. Accordingly, the culture scaffold of the present disclosure having excellent bone regeneration…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.