Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
US10631746B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 9, 2014 |
| Grant date | Apr 28, 2020 |
| Priority date | — |
| Expiry date | Aug 4, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/6826
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method, an apparatus, and a kit including the apparatus and a fluorescence agent are provided for measuring a time-varying change in an amount of blood in a tissue volume, and include exciting a fluorescence agent in the blood, acquiring a time-varying light intensity signal during a pulsatile flow of the blood through the tissue volume, the pulsatile flow having a systolic and a diastolic phase resembling a conventional photoplethysmogram, and processing the acquired signal by applying a modified Beer-Lambert law to obtain a measurement of the time-varying change in the amount of blood in the tissue volume. The instantaneous molar concentration of the fluorescence agent is determined by utilizing a concentration-mediated change in a fluorescence emission spectrum of the fluorescence agent. There is further provided a fluorescence agent for use in the method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.