Injectable self-assembling antibacterial peptide hydrogels

US10632172B2 · kind B2 · utility

Assignee

• New Jersey Institute of Technology · US

Inventors

• Vivek Kumar · Delhi, IN
• Peter Q. Nguyen · Malden, US
• Biplab Sarkar · Newark, US
• Shivani Jaisinghani · Morganville, US

Key dates

• Filing date: Jun 12, 2019
• Grant date: Apr 28, 2020
• Expiry date: Jun 12, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A set of cationic amphiphilic self-assembled peptides (CASPs) is presented that employ high-charge density at fiber edges to disrupt bacterial membranes. CASP nanofibers are effective against Pseudomonas biofilms. There is an inherent trade-off between the ability of the peptides to undergo nanofibrous self-assembly and having a high terminal charge density required for effective bactericidal efficacy. The self-assembled peptide hydrogel presented achieves a balance of these opposing factors. Also demonstrated is the applicability of the new composition in an injectable hydrogel formulation. A CASP platform may be useful for topical application and integration into medical coatings, grafts, devices, and prostheses, thereby reducing risk of bacterial infection and related failure.