Apparatus for a mass production of monodisperse biodegradable polymer-based microspheres and a multi-channel forming device incorporatable therein
US10632442B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 20, 2017 |
| Grant date | Apr 28, 2020 |
| Priority date | — |
| Expiry date | Jun 30, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08J2367/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method and an apparatus for a large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems and design optimization method for the apparatus are provided. The method uses a plurality of microchips, each microchip having at least a first pathway, a second pathway and an outlet, wherein the first pathway and the second pathway merge at a cross point being one end of the outlet, and the method comprises preparing a polymer-phase solution including a degradable polymer and a water-phase solution including a surfactant, having the polymer-phase solution flow through the first pathway, having the water-phase solution flow through the second pathway, gathering a mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the water-phase solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.