Microfluidic devices and related methods

US10632464B2 · kind B2 · utility

Assignee

• ALERE SAN DIEGO, INC. · US

Inventors

• Alexander Schenk zu Schweinsberg · Jena, DE
• Austin M. Derfus · San Diego, US
• Justin Davidson · San Jose, US
• Karthikeyan Kumaravadivelu · San Diego, US
• Maulik Vinod Patel · La Cañada Flintridge, US
• Olaf Piepenburg · St Albans, GB
• Catherine Jean Greenwood · Sawbridgeworth, GB
• Oliver Nentwich · Cambridge, GB

Key dates

• Filing date: Feb 27, 2018
• Grant date: Apr 28, 2020
• Expiry date: Feb 27, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2035/1034
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.