Synthesis of bicyclo[2.2.2]octanes
US10633315B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Oct 11, 2017 |
| Grant date | Apr 28, 2020 |
| Priority date | — |
| Expiry date | Oct 11, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst comprising a palladium compound to afford certain oxo-substituted bicyclo[2.2.2]octane species. The process of the invention thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.