Phenyl indole allosteric inhibitors of p97 ATPase

US10633370B2 · kind B2 · utility

Assignees

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US
• National Institutes of Health, A Component of the U.S. Department of Hearth and Human Services · US
• The Regents of the University of California · US

Inventors

• Donna M. Huryn · Allentown, US
• Peter Wipf · Pittsburgh, US
• Matthew G. LaPorte · Girard, US
• Raffaele Colombo · Pittsburgh, US
• Marina Kovaliov · Pittsburgh, US
• Chaemin Lim · Pittsburgh, US
• Celeste Natalie Alverez · Pittsburgh, US
• Zhizhou Yue · Pittsburgh, US
• Lalith Palitha Samankumara · Pittsburgh, US
• Alexander Julian Chatterley · Pittsburgh, US
• Yongzhao Yan · Pittsburgh, US
• Mary Liang · Pittsburgh, US
• Neal Green · Newton, US
• Eric T. Baldwin · Carmel, US
• William J. Moore · Hagerstown, US
• Michelle Arkin · San Francisco, US
• R. Jeffrey Neitz · San Francisco, US
• Kean-Hooi Ang · Singapore, SG
• Clifford Bryant · Millbrae, US
• Stacie Bulfer · Oakland, US

Key dates

• Filing date: Oct 20, 2016
• Grant date: Apr 28, 2020
• Expiry date: Oct 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.