BET protein degraders

US10633386B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Bing Zhou · Ann Arbor, US
• Fuming Xu · Ypsilanti, US
• Jiantao Hu · Ann Arbor, US
• Longchuan Bai · Ann Arbor, US
• Chao-Yie Yang · Hangzhou City, CN

Key dates

• Filing date: Apr 6, 2017
• Grant date: Apr 28, 2020
• Expiry date: Apr 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0808
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein B, R1, R5, Q1, Q″, L, X, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.