Method and apparatus for diagnosing a tumor using a histogram and excluding abnormal fluorescence corresponding to DNA aneuploidy
US10633709B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 19, 2017 |
| Grant date | Apr 28, 2020 |
| Priority date | — |
| Expiry date | Dec 26, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/6439
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An apparatus and a method for diagnosing a tumor are provided. A histogram generating section generates a histogram from a result of a measurement of fluorescence intensity of a suspension produced from a target sample. The histogram indicates a relation between the fluorescence intensity and the number of cells. A determination section detects an S phase fluorescence intensity range corresponding to S phase cells based on the fluorescence intensity corresponding to a peak of the number of cells in the histogram, detects an abnormal fluorescence intensity range corresponding to tumor cells, based on a change in the number of cells in the S phase fluorescence intensity range, and performs a diagnosis of a tumor in the target sample based on an index of the number of cells in a range defined by excluding the abnormal fluorescence intensity range from the S phase fluorescence intensity range.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.