Aldose reductase inhibitors and uses thereof

US10639306B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Andrew WASMUTH · Brooklyn, US
• Donald W. Landry · New York, US
• Shixian Deng · White Plains, US
• Banavara L. Mylari · Lutz, US
• Ravichandran Ramasamy · Ardsley, US
• Ann Marie Schmidt · Franklin Lakes, US

Key dates

• Filing date: Mar 5, 2019
• Grant date: May 5, 2020
• Expiry date: Mar 5, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.