Tubulin inhibitor

US10640492B2 · kind B2 · utility

Assignee

• SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. · CN

Inventors

• Tian Tang · Tangxia, CN
• Yanqing Wang · Jiaozuo City, CN
• Xiaorou Liu · Tangxia, CN
• Jin Wang · Sugar Land, US
• Ruyi Jin · Tangxia, CN
• Hanlin Feng · Nanhu, CN

Key dates

• Filing date: Sep 29, 2017
• Grant date: May 5, 2020
• Expiry date: Sep 29, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a new tubulin inhibitor and applications thereof, the tubulin inhibitor being a series of compounds based on substituted heterocyclic skeletons, targeting the colchicine binding sites of tubulin. The structure is: Formula (I), wherein: formula (A), n independently expresses an integer between 0 and 5, the condition being that n≤5, A represents mono- or poly-substituted groups, the groups being selected from the group consisting of H, C1-C20 amide group, C1-C20 acyloxy group, C1-C20 alkanoyl group, C1-C20 alkoxycarbonyl group, C1-C20 alkoxy group, C1-C20 alkylamino group, C1-C20 alkylcarboxyamino group, aroyl group, aralkanoyl group, carboxyl group, cyano group, halogen group, hydroxyl group, nitro group and methylthienyl group.