T cell-antigen coupler with various construct optimizations
US10640562B2 · kind B2 · utility
13Cited by
1References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 14, 2019 |
| Grant date | May 5, 2020 |
| Priority date | — |
| Expiry date | Jun 14, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.