Human mesothelin chimeric antigen receptors and uses thereof

US10640569B2 · kind B2 · utility

Assignees

• Novartis AG · CH
• The Trustees of the University of Pennsylvania · US

Inventors

• Gregory Beatty · Philadelphia, US
• Boris Engels · Arlington, US
• Neeraja Idamakanti · Burlington, US
• Carl H. June · Yeadon, US
• Andreas Loew · Somerville, US
• Huijuan Song · Shanghai, CN
• Qilong Wu · Shanghai, CN

Key dates

• Filing date: Dec 19, 2014
• Grant date: May 5, 2020
• Expiry date: Dec 19, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/15041
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor(CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.