Patent · US Active

Biomarkers for head and neck cancer and methods of their use

US10640831B2 · kind B2 · utility

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4Claims

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Assignee

The Regents of the University of Colorado, a Body Corporate · US

Inventors

Shi Lu · San Ramon, US
John Song · Nashville, US

Key dates

Filing date	Oct 16, 2015
Grant date	May 5, 2020
Priority date	—
Expiry date	Nov 18, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/178
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (HNSCC). These results represent the first use of quantitative MS-PCR for the detection of mgmiRs. In addition this panel demonstrates the ability to detect hypermethylation in the adjacent mucosa of cancer patients, suggesting its utility in early detection. This panel is also capable of detecting cancer by using saliva, blood and FNA tissue samples.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.